A mathematical model for the germinal center morphology and affinity maturation.
نویسنده
چکیده
During germinal center reactions, the appearance of two specific zones are observed: the dark and the light zone. Up to now, the origin and function of these zones are poorly understood. In the framework of a stochastic and discrete model, several possible pathways of zone development during germinal center reactions are investigated. The importance of the zones in the germinal center for affinity maturation, i.e. the process of antibody optimization is discussed.
منابع مشابه
The relation of morphology and affinity maturation in germinal centers
The specific morphology of germinal centers is analyzed in the context of the optimization of the humoral immune response. The relevance of dark and light zones for the affinity maturation process is investigated in the framework of a theoretical model for the germinal center reaction. Especially, it is shown that an intermediate appearance of dark zones in germinal center reactions is advantag...
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ورودعنوان ژورنال:
- Journal of theoretical biology
دوره 216 3 شماره
صفحات -
تاریخ انتشار 2002